Pirfenex 400 Mg

Last Updated on 05/19/2026 ✔ Medically Reviewed by Dr. Arjun Srivastav

What Is Pirfenex 400 Mg?

Pirfenex 400 mg contains pirfenidone, an antifibrotic and anti-inflammatory medicine used to slow down lung scarring.

Pirfenex is a medicine for the treatment of lung fibrosis. In simple words, it means that the soft lung tissues inside the patient have scarred marks on them and suffer from inflammation.

Using this drug, which has the generic element Pirfenidone, helps to reduce this scarring and inflammation, which is helpful for patients to breathe and survive longer.

Manufacturer:

• Cipla Limited, in India, is the manufacturer of the brand-name Pirfenex 400 mg.

Composition And Appearance:

✓ Active ingredient:

Pirfenidone is the chief generic element, with each medicine having 400 mg of the generic substance.

✓ Inactive ingredients:

Titanium dioxide, which is used as a colouring agent, and some standard and regulated binders are also present in the medicine, but do not help in the treatment.

✓ Appearance:

It is a film-coated tablet with each medicine generally being round or slightly oval. Colour-wise, it is typically white to off-white.

Onset Of Action:

✓ Absorption:

If taken on an empty stomach, the medicine starts absorption within an hour. However, if taken after food, it can take up to three to 4 hours for absorption of the drug to begin.

✓ Stabilization:

You will see that your lung function gets better, or your symptoms are not as bad, after you use this treatment for three to six months every day.

✓ Long-term Effects:

When doctors do studies over a year, they see improvements, like your lungs not getting worse as fast, after you have been using the treatment for twelve months.

Uses of Pirfenex 400 mg

Pirfenex 400 mg (pirfenidone) is primarily used to slow down lung scarring and improve breathing function.

Idiopathic Pulmonary Fibrosis (IPF)

• Slow the progression of lung fibrosis (scarring)
• Helps maintain lung function
• Reduces the decline in breathing capacity
• Helps slow down lung scarring and disease progression

How Pirfenex 400 Mg Works?

✓ Inhibits TGF- beta:

Pirfenex stops TGF-β, which is also known as Transforming Growth Factor-β, from working.

When Pirfenex blocks TGF-β, it prevents the cells in our lungs called fibroblasts from turning into myofibroblasts. Myofibroblasts are the cells that make much scar tissue.

✓ Reduces Collagen Production:

Pirfenex 400 helps to decrease the amount of collagen that our body makes. It also stops collagen and other things from building up in our bodies.

✓ Stops Cells from Multiplying Too Fast:

This thing directly stops fibroblasts from multiplying quickly. If that does not happen, the lungs will have a buildup of tissue that does not work properly.

✓ Anti -inflammatory effect:

Pirfenex lowers the levels of things like TNF-alpha and Interleukin-6 in the body. Pirfenex reduces swelling and inflammation in the lungs.

✓ Antioxidant properties:

Pirfenex helps stop radicals from causing damage. Pirfenex reduces stress, which protects the cells in the lungs from getting hurt even more.

Dosage Of Pirfenex:

• Day 1-7: 1 tablet of 200 mg thrice a day with food.
• Day 8-14: 2 Tablets of 400 mg thrice a day with food.
• For Maintenance: Follow the doctor’s instructions.

Effect Timeline

• Works gradually over weeks to months
• Helps slow disease progression, not treat it

Benefits Of Pirfenex 400 Mg:

✓ Prevents lung function:

It helps keep the lungs working. It can slow down how fast lung function gets worse by as much as 50%.

✓ Improve survival rate:

This treatment can lower the risk of dying from any cause and from IPF specifically.

✓ Reduce acute exacerbations:

It prevents bad turns: It greatly reduces the risk of sudden severe worsening of symptoms and hospital stays, for these issues.

✓ Easier Breathing:

The lung tissues have scarring and swelling, so patients with lung problems can breathe deeply and easily. This is helpful for people who have trouble breathing.

✓ Symptom Reduction:

It helps patients deal with symptoms that never seem to go away, such as being short of breath and having a dry cough.

Drug Interactions:

1. Critical Drug Interactions:

✓ Fluvoxamine:

Avoid it, as it is an inhibitor of CYP1A2. If needed, ed the doctors can recommend a very small dose with extra precautions.

✓ Ciprofloxacin:

If you take it with Pirfenex, the level of Pirfenidone in your body can go up by 81%. Your doctor may need to adjust your dose if you have to take this antibiotic.

✓ Other inhibitors:

Medications like Enoxacin, Amiodarone, and Propafenone are examples of this. These medications can make the blood levels of medications go up. This can also increase the side effects of these medications.

2. Medicines That Reduce Effectiveness:

✓ Rifampicin:

This medicine fights infections like tuberculosis. It can greatly lower the amount of Pirfenex in your blood.

✓ Medicines for seizures:

Drugs, like Carbamazepine, Phenobarbital, and Primidone,e can make Pirfenex less effective.

Precautions And Warnings:

✓ Liver Function Monitoring:

You need to have blood tests to check if your liver is working properly. If you notice any yellowing of your skin or eyes, urine, or pain in the upper right part of your belly, tell your doctor right away.

✓ Photosensitivity:

Taking Pirfenex 400 makes your skin more sensitive to the sun. To protect yourself, you use a sunscreen that protects against UVA and UVB rays and has an SPF of 50 or more every day.

✓ Avoid Smoking:

You should not smoke because it can make the drug leave your body faster. This can make the drug not work well. In fact, smoking can make the drug less effective by half.

✓ Gastrointestinal Management:

When you take the tablet, you should take it with food. After you have eaten. This can help with the side effects like feeling sick, having stomach problems, throwing up, or having an upset stomach.

✓ Alertness and Driving:

You should be careful when you take Pirfenex because it can make you feel dizzy or sleepy, or it can blur your vision. Therefore, it is an idea to wait and see how Pirfenex affects you before you drive a car or use heavy machinery.

✓ Dietary Restrictions:

When you are taking Pirfenex, you should not eat grapefruit. Drink grapefruit juice.

This is because grapefruit and grapefruit juice can affect how your liver works with Pirfenex, nd this can cause problems with your blood levels of Pirfenex.

✓ Alcohol Use:

Pirfenex 400 is important to stay away from alcohol or only have a little bit because it can hurt the liver and make you feel extremely dizzy.

When Not To Use:

✓ Severe liver and kidney disorders:

If you have bad liver disease or bad kidney disease that needs dialysis, do not take this medication.

✓ Avoid in children:

This medication is for adults. You should not give it to children who are under 18 years of age.

✓ Pregnancy and Breastfeeding:

Pirfenex 400 is not usually recommended when you are pregnant or breastfeeding. This is because it may harm your baby. You should talk to your doctor to find out what risks are involved.

Storage And Disposal:

✓ Storage:

• Store below 25°C
• Keep in a cool, dry place away from sunlight and moisture

✓ Disposal:

Discard empty sachets safely in a disposal bag. Never use expired medicines as they can cause severe side effects. Ensure you discard those in a separate disposal bag to avoid any risk of contamination.

Where To Buy Pirfenex 400 Mg In Australia?

You can rely on trusted platforms such as australiarxmeds.com for secure and discreet delivery across Australia.

Pirfenex 400 is available for online purchase through pharmacy websites, but it’s important to choose reputable and licensed sellers to guarantee product quality, authenticity, and safety.